What Does Mitochondrial transfer Means?

Mitochondrial transplant is a process that succeeds in isolated mitochondria in the stem cell first. In other words, aging cells in the body are taken and transferred to the woman’s eggs. For mitochondria transplant, 5 millimeters of tissue are taken first by the closed surgery method, and then the leading cells are separated from this tissue by a special procedure. The most important feature of the cells is that they can repair DNA damage.

What Is Mitochondria?

Mitochondria are one of the cell organelles. It is derived from the Greek words misos (yarn) and chondroid (grain). Their length varies between 0.2-5 microns. Their shape varies from oval to stick. Although some cells may contain a single large mitochondrion, mitochondria are often abundant in cells. Their number varies depending on the cell’s energy needs. There are many mitochondria in cells that need more energy, especially muscle and nerve cells. Their number can reach about 2500 in a liver cell.

Is It Possible To Improve The Health Of Our Mitochondria?

There are two different approaches to this purpose in reproductive health and infertility treatments. Although many commercial multivitamin/supplement products are marketed for this purpose and whose regular use is stated to have a positive effect on reproductive health, studies show that only a few of these products (coenzyme Q10; CoQ10, etc.) can be useful.

Besides, the use of these products in women who are genetically predisposed to genetically significant unhealthy mitochondria is not beneficial.

For this purpose, the second approach, which is still experimentally applied today, is the method of transmitting mitochondria, which are considered to be healthy, to the candidate women ‘eggs using micro-surgical methods performed in clinical and laboratory, and thus increasing the quality/health of the eggs.

The latest application developed for people who want to have children is IVF treatment. This method, known as mitochondria transplant, is being explored by many citizens.

WHAT IS MITOCONDRIALTRANSPLANT TEST TUBE BABY TREATMENT?

The decrease in the quality of the eggs is due to the increase in the rate of chromosome aneuploidy associated with aging, associated with meiosis errors during egg maturation. However, with the role of mitochondria in the development of newly introduced eggs; Egg quality can be improved by applying a combination of energy-requiring nuclear, cytoplasmic, and epigenetic changes provided by the oocyte, the egg ripening process, oxidative phosphorylation (OXPHOS).

Mitochondria in the reproductive cell decrease with aging in women. Therefore, mitochondria transplantation can be applied to women in older ages, young women with impaired egg quality, that is, any woman whose egg quality is impaired.

In the case where sperms and egg donor’s eggs are transplanted while creating embryos with someone else’s genetic structure, we can use the Mitochondria transplantation technique while using Intended parent’s eggs and sperms.

Since the Mitochondria transplantation process is a very new technique and still in research stages the success rate with this process is very low currently.